IDENTIFICATION OF CORRELATION BETWEEN TOTAL ORGANIC CARBON AND CONDUCTIVITY VALUES OF WATER FOR INJECTION LINE AND ESTABLISHING TOTAL ORGANIC CARBON RANGE FOR A SPECIFIC CONDUCTIVITY VALUE AT A WATER FOR INJECTION LINE / LOOP OF A SPECIFIC WATER SYSTEM
DOI:
https://doi.org/10.20535/2218-930022025342596Keywords:
pharmaceutical facility, total organic carbon, water for injection, water qualityAbstract
The present study investigated the relationship between conductivity and total organic carbon (TOC) values in water for injection (WFI) systems at a pharmaceutical facility in Uttarakhand. Measurements were taken at the inlet and outlet of water for injection return loops across three separate blocks over a 90-day period from October 2024 to January 2025. The findings indicated that each block required a distinct total organic carbon range, as total organic carbon levels, while generally correlated with conductivity, were also influenced by factors such as pipeline length, diameter, and number of user points. Importantly, total organic carbon values could exceed specifications even if conductivity was within acceptable limits, highlighting the critical need for block-specific total organic carbon monitoring. Moreover, the total organic carbon range w.r.t. conductivity values can be defined based on the trends observed at specific water systems and these are more accurately illustrating the actual total organic carbon results and also can be hypothecated based on the online conductivity results of a water system or water for injection distribution system used in pharmaceutical industries. The study concludes that defining total organic carbon ranges relative to conductivity trends enhances water quality monitoring for pharmaceutical processes and ensures accurate control over organic contamination.
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